Queen Mary University of London

TILLI Study

Thromboprophylaxis in lower limb immobilisation after injury.

The TILLI Study is investigating the best way to prevent blood clots in people with lower limb injuries.

The study compares different blood-thinning medicines to understand which approach is most clinically effective and cost-effective for patients at higher risk. Blood clots, known as venous thromboembolism, can cause serious illness and may become life-threatening if they travel to the lungs. The findings will help inform future guidance on preventing blood clots in patients with lower limb injuries.

Morph solution

Morph supported the TILLI Study with our Patient Information Solution, providing a Patient Information Animation and an interactive Patient Information Tool.

Patient Information Animation – a clear, visually engaging animation explaining what taking part in the TILLI study involves. Designed to summarise the key points of the patient information, it helped participants understand the trial before reviewing the full written document.
Patient Information Tool (PIT) – an interactive digital version of the patient information sheet, allowing participants to review the information step by step in full-screen mode, with the option to switch language.

Both the animation and the tool were translated into Romanian, Polish and Punjabi, including voiceover, in-video text and subtitles, helping make the information accessible to a wider range of participants.

TiLLI Study video

If you have a lower limb injury, you may need to wear a plaster cast or a boot to support your leg while it heals.

While your leg is immobilised, the blood in your veins may not flow as well as usual.

This can increase the risk of developing a blood clot.

Blood clots that form in the veins are known as venous thromboembolism, or VTE.

A blood clot can cause swelling and pain in the leg.

In some cases, a clot can travel to the lungs.

This is called a pulmonary embolism and can be life-threatening.

Doctors sometimes prescribe blood-thinning medicines to reduce the risk of clots forming.

However, these medicines can also increase the risk of bleeding.

The TILLI Study is looking at the best way to prevent blood clots in people with lower limb injuries who may be at risk.

The study is comparing different blood-thinning medicines to understand which treatment works best and is most cost-effective.

If you decide to take part, you will be asked to sign a consent form.

You will also be asked to complete some short questionnaires about your health.

Your treatment will be decided randomly by a computer.

This means that neither you nor your doctor will choose which treatment you receive.

During the study, we will follow up with you to see how you are recovering.

Taking part is voluntary and you can leave the study at any time.

The results of this study will help doctors understand how best to prevent blood clots in people with lower limb injuries in the future.

Morph are fantastic to work with and are our go to here at Bone & Joint Health, QMUL. They bring a deep understanding of clinical research, have a clear process for collaboration and always deliver results that exceed expectations.

Jamila Kassam, Academic Strategic Lead, Centre for Bone and Joint Health